Teilo hosted the irAE symposium to share the progress and discuss future directions for the irAE field.

Introduction and Opening Remarks

Introduced to Project Data Sphere (PDS) and the event’s program; Presented overview of the landscape around ICIs and irAEs, and the beginning of the irAE-related work with the MGH and PDS teams; Patient Advocate Dr. Santamarina underscores the importance of work in this field by sharing her own personal experiences.

Teilo Schaller, PHD, Project Data Sphere, Program DirectorKerry L. Reynolds, MD, Massachusetts General Hospital | Harvard Medical School, OncologistDr. Regina Echeverria-Santamarina, Patient Advocate

Project Overview – Neurologic irAEs

Detailed the work involved in completing the neurologic irAE Delphi definitions project. Discussed the project’s next steps focusing on building a neurologic irAE patient registry.

Amanda Guidon, MD, Massachusetts General Hospital | Harvard Medical School, Neurologist Leeann B. Burton, MD, Massachusetts General Hospital | Harvard Medical School, Neurologist

Project Overview -Dermatologic irAEs

Presented the project plan for dermatologic irAE definitions, translational research aims, and some of the project’s next steps.

Steven T. Chen, MD MPH MS-HPEd, Massachusetts General Hospital | Harvard Medical School, Dermatologist/InternistNicole R. Leboeuf, MD MPH, Dana Farber/Brigham and Women’s Cancer Center, Harvard Medical School, DermatologistYevgeniy R. Semenov, MD MA, Massachusetts General Hospital | Harvard Medical School, Dermatologist

Panel Discussion: Surveying the irAE landscape in various fields

Interviewed by: Andrew K. Crighton, MD, CEO Roundtable on Cancer | Project Data Sphere, CEO

Discussed barriers and challenges – and their potential solutions – around irAEs and ICIs that each expert sees from their various fields.

Mark Anderson, MD, PHD, UCSF Diabetes Center, Interim DirectorShaily Arora, Ph.D, FDA, Oncology Center for Excellence, Associate Director for SafetyElad Sharon, MD, MPH, National Cancer Institute, Senior InvestigatorDr. Ky Trang, MD, EMD Serono, Safety Physician

Closing Remarks 

Highlighted the substantial progress of the irAE program’s work, as well as its promising future. Thank you to all the speakers, panelists, and attendees.

Bill Louv, PHD, Project Data Sphere, President

Video Links

Introductions and Opening Remarks

Panel Discussion and Closing Remarks